1/14/2024 0 Comments Calcium casa xps![]() ![]() Etidronate acid and clodronic acid were the first two bisphosphonates used in medical practice. They were then introduced to the field of medicine in the late 1960s for the treatment of diseases that affect bone metabolism. īisphosphonates first appeared on the industrial scene in the 19th century when their unique structural properties were used to ‘soften water’ to prevent scaling and corrosion of pipes. Studies have shown that the use of bisphosphonates reduces the risk of vertebral and hip fractures by 30%-70% in women with osteoporosis. Because of their antiresorptive qualities, bisphosphonates are widely used in the treatment of osteoporosis. The use of bisphosphonates in patients with multiple myeloma and metastatic bone disease has led to a reduced incidence of pathological fractures. Bisphosphonates are the cornerstone in the management of metabolic and cancer-related bone disease.
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